Sinclair Method Studies

Published on: 11/06/2025

This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

The Sinclair Method: A Revolutionary Approach to Alcohol Harm Reduction

Published on: 03/04/2025

The Sinclair Method (TSM) is an evidence-based treatment for Alcohol Use Disorder (AUD) that diverges from traditional abstinence-focused approaches. Developed by Dr. John David Sinclair, TSM employs the opioid antagonist naltrexone to disrupt the brain's association between alcohol consumption and pleasurable sensations. This process, known as pharmacological extinction, gradually diminishes the desire to drink.

The Sinclair Method (TSM)

Why Support Is Essential for Success on The Sinclair Method: It's Not Just a Pill

Published on: 26/03/2025

When many people first hear about The Sinclair Method (TSM), they assume it's just about taking a pill. Simple, right? Pop naltrexone before drinking, and eventually lose the urge. But here's the truth: success on TSM isn't just about the medication — it's about the method, the mindset, and most importantly, the support.

The Sinclair Method (TSM)

The History of the Sinclair Method

Published on: 04/12/2024

This blog post will explore the history of the Sinclair Method, the clinical trials that followed, and its significance in the ongoing battle against alcoholism.

The Sinclair Method (TSM)